Review Article

Amyloidogenic proteins and occurrence of different amyloidosis in different animal species

Patrycja Florczuk-Kołomyja, Paweł Kołomyja , Wiesław Świderek , Joanna Gruszczyńska

Department of Animal Genetics and Conservation, Institute of Animal Sciences Warsaw University of Life Sciences – SGGW, Ciszewskiego 8, 02-786 Warsaw, Poland

Abstract. Amyloidosis is a poly-systemic disease caused by extracellular deposition of biologically inactive amyloid proteins, most often in kidneys, liver, nervous system, thyroid, spleen and heart. Depending on the site of production and deposition they can be classified into causing localised (organ-limited) and systemic amyloidosis. Disturbances in functioning of individual organs occur with an increase of the amount of accumulated protein what in turn may lead to the death of the affected individual. The occurrence of amyloidosis has been reported in human, but in animals, the most common form is AA amyloidosis, while AL amyloidosis is the least common. Due to the fact that symptoms of amyloidosis vary and often resemble those occurring in the course of other diseases, it is difficult to diagnose. Treatment of amyloidosis is aimed at improving functioning of the affected organs, yet the disease is incurable.

Keywords: amyloid proteins, localized amyloidosis, systemic amyloidosis

 

This Article
Article in Press

Received: 27 Aug 2020

Accepted: 15 Sep 2020

Published online: 11 Oct 2020

Accesses: 10

How to cite

Florczuk-Kołomyja, P., Kołomyja, P., Świderek, W., Gruszczyńska, J., (2020). Amyloidogenic proteins and occurrence of different amyloidosis in different animal species. Acta Sci. Pol. Zootechnica, 19(3), in press.