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Review Article

Genetic background of chondrodysplasia in domestic dog (Canis lupus familiaris) – in silico analysis

Patrycja Florczuk, Joanna Gruszczyńska

Department of Genetics and Animal Breeding Faculty of Animal Science, Warsaw University of Life Sciences WULS-SGGW Ciszewskiego 8, 02-786 Warsaw, Poland

1. Acta Sci. Pol. Zootechnica, 15(4), 2016, 5‒14
2. DOI: 10.21005/asp.2016.15.4.01

Abstract. Chondrodysplasia is a type of genetic skeletal disorder associated with abnormalities in the development of cartilage tissues. Affected dogs suffer from disproportionate short-limbed dwarfism and/or hyperplasia of the skull bones. Visible symptoms occur only during growth period. Early studies demonstrated that chondrodysplasia in domestic dog is an autosomal recessive disease. Therefore, the only way to detect carriers in the population without performing test matings is a genetic test. Current knowledge of the genetic background of chondrodysplasia is limited to Norwegian Elkhound and Karelian Bear Dog. In case of other breeds, for example Labrador Retriever, known research only excludes participation of certain genes in the origin of the disease. Therefore, the authors of this article decided to develop diagnostic genetic tests that will detect carriers on the basis of previously identified mutations, causing chondrodysplasia.

Keywords: chondrodysplasia, domestic dog, Labrador Retriever, COL11A2, Norwegian Elkhound, ITGA10